GYIG OpenIR  > 环境地球化学国家重点实验室  > 期刊论文
Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment
Yunyun Li; Yuqin Fan; Jiating Zhao; Xiaohan Xu; Hui Jing; Lihai Shang; Yuxi Gao; Bai Li; Yu-Feng Li
2016
Source PublicationBioMetals
Volume29Issue:5Pages:893-903
Abstract
Methylmercury is a toxic pollutant and is generated by microbial methylation of elemental or inorganic mercury in the environment. Previous study found decreased hepatic MDA levels and urinary mercury levels in methylmercury poisoned rats after sodium selenite treatment. This study further found increased mercury levels in serum samples from methylmercury poisoned rats after selenium treatment. By using size exclusion chromatography coupled to inductively coupled plasma mass spectrometry, three Hg- binding protein fractions and two Se-binding protein fractions were identified with the molecular weight of approximately 21, 40, and 75 kDa and of 40 and 75 kDa, respectively. Elevated mercury level in the 75 kDa protein fraction was found binding with both Hg and Se, which may explain the decreased urinary Hg excretion in MeHg poisoned rats after Se treatment. MALDI-TOF-MS analysis of the serum found that the 75 kDa protein fractions were albumin binding with both Hg and Se and the 21 kDa fraction was Hg- binding metallothionein.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.gyig.ac.cn/handle/352002/6558
Collection环境地球化学国家重点实验室_环境地球化学国家重点实验室_期刊论文
Recommended Citation
GB/T 7714
Yunyun Li,Yuqin Fan,Jiating Zhao,et al. Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment[J]. BioMetals,2016,29(5):893-903.
APA Yunyun Li.,Yuqin Fan.,Jiating Zhao.,Xiaohan Xu.,Hui Jing.,...&Yu-Feng Li.(2016).Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment.BioMetals,29(5),893-903.
MLA Yunyun Li,et al."Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment".BioMetals 29.5(2016):893-903.
Files in This Item:
File Name/Size DocType Version Access License
Elevated mercury bou(4103KB) 开放获取LicenseView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yunyun Li]'s Articles
[Yuqin Fan]'s Articles
[Jiating Zhao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yunyun Li]'s Articles
[Yuqin Fan]'s Articles
[Jiating Zhao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yunyun Li]'s Articles
[Yuqin Fan]'s Articles
[Jiating Zhao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.